@article{91,
  keywords = {Hodgkin-Huxley networks, Local field potential, PV interneurons, Pavlovian fear conditioning, SOM interneurons, Theta rhythm, VIP interneurons, biomarker, gamma rhythm, spike-timing-dependent plasticity},
  author = {Anna Cattani and Don Arnold and Michelle McCarthy and Nancy Kopell},
  title = {Basolateral amygdala oscillations enable fear learning in a biophysical model.},
  abstract = {<p>The basolateral amygdala (BLA) is a key site where fear learning takes place through synaptic plasticity. Rodent research shows prominent low theta (~3-6 Hz), high theta (~6-12 Hz), and gamma (\&gt;30 Hz) rhythms in the BLA local field potential recordings. However, it is not understood what role these rhythms play in supporting the plasticity. Here, we create a biophysically detailed model of the BLA circuit to show that several classes of interneurons (PV, SOM, and VIP) in the BLA can be critically involved in producing the rhythms; these rhythms promote the formation of a dedicated fear circuit shaped through spike-timing-dependent plasticity. Each class of interneurons is necessary for the plasticity. We find that the low theta rhythm is a biomarker of successful fear conditioning. The model makes use of interneurons commonly found in the cortex and, hence, may apply to a wide variety of associative learning situations.</p>},
  year = {2024},
  journal = {bioRxiv : the preprint server for biology},
  month = {10/2024},
  issn = {2692-8205},
  language = {eng},
}