I am a basic neuroscientist but have spent my entire academic career in psychiatry. I focused on aging and dementia in the first 25 years, and on psychosis in the last 25 years.  While much of my work in psychosis focused on hallucinations and delusions, the so-called ‘positive symptoms,’ I also focus on cognitive deficits reported to underlie poor functional outcomes for people with schizophrenia. While much of my career has focused on EEG-based methods to understand both normal and abnormal brain function, I have been using functional magnetic imaging (fMRI) in the last two decades to address functional dysconnectivity in schizophrenia, with a focus on thalamus, pons, and cerebellum and their associations with psychotic symptoms like delusions and hallucinations.  Most recently, I have been conducting an NIMH-funded mechanistic clinical trial on the effects of a ketogenic diet on dynamic neural stability in people with schizophrenia and bipolar disorder.  This work brings together cardiovascular metabolism and psychiatry to address two problems experienced by people with psychosis: neural network instability (associated with cognitive deficits and poor outcomes) and insulin resistance/metabolic syndrome (associated with elevated morbidity and mortality).